Neural activity and the dynamics of central nervous system development

JY Hua, SJ Smith - Nature neuroscience, 2004 - nature.com
JY Hua, SJ Smith
Nature neuroscience, 2004nature.com
Recent imaging studies show that the formation of neural connections in the central nervous
system is a highly dynamic process. The iterative formation and elimination of synapses and
neuronal branches result in the formation of a much larger number of trial connections than
is maintained in the mature brain. Neural activity modulates development through biasing
this process of formation and elimination, promoting the formation and stabilization of
appropriate synaptic connections on the basis of functional activity patterns.
Abstract
Recent imaging studies show that the formation of neural connections in the central nervous system is a highly dynamic process. The iterative formation and elimination of synapses and neuronal branches result in the formation of a much larger number of trial connections than is maintained in the mature brain. Neural activity modulates development through biasing this process of formation and elimination, promoting the formation and stabilization of appropriate synaptic connections on the basis of functional activity patterns.
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