Glycosaminoglycan accumulation with partial deficiency of β-glucuronidase in the C3H strain of mice

S Yatziv, RP Erickson, R Sandman, WB Robertson - Biochemical Genetics, 1978 - Springer
S Yatziv, RP Erickson, R Sandman, WB Robertson
Biochemical Genetics, 1978Springer
Abstract Young (60–80 days) mice of the low β-glucuronidase strain, C3H/HeJ, showed no
differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the
randombred,“normal” Swiss-Webster mice of the same age. However, by 12 months of age
hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of β-
glucuronidase, β-galactosidase, and N-acetyl-β-glucosaminidase in four tissues of the two
types of mice at the two ages revealed that glucuronidase was the only enzyme with lower …
Abstract
Young (60–80 days) mice of the low β-glucuronidase strain, C3H/HeJ, showed no differences in hepatic levels of glycosaminoglycans (GAGs) when compared to the randombred, “normal” Swiss-Webster mice of the same age. However, by 12 months of age hepatic GAG is nearly twice as high in C3H/HeJ mice as in Swiss-Webster mice. Studies of β-glucuronidase, β-galactosidase, and N-acetyl-β-glucosaminidase in four tissues of the two types of mice at the two ages revealed that glucuronidase was the only enzyme with lower activity in the C3H/HeJ strain.
Springer