Genotoxicity of tobacco smoke and tobacco smoke condensate: a review
DM DeMarini - Mutation Research/Reviews in Mutation Research, 2004 - Elsevier
This report reviews the literature on the genotoxicity of mainstream tobacco smoke and
cigarette smoke condensate (CSC) published since 1985. CSC is genotoxic in nearly all
systems in which it has been tested, with the base/neutral fractions being the most
mutagenic. In rodents, cigarette smoke induces sister chromatid exchanges (SCEs) and
micronuclei in bone marrow and lung cells. In humans, newborns of smoking mothers have
elevated frequencies of HPRT mutants, translocations, and DNA strand breaks. Sperm of …
cigarette smoke condensate (CSC) published since 1985. CSC is genotoxic in nearly all
systems in which it has been tested, with the base/neutral fractions being the most
mutagenic. In rodents, cigarette smoke induces sister chromatid exchanges (SCEs) and
micronuclei in bone marrow and lung cells. In humans, newborns of smoking mothers have
elevated frequencies of HPRT mutants, translocations, and DNA strand breaks. Sperm of …