[HTML][HTML] Decreased perforin and granzyme B expression in senescent HIV-1-specific cytotoxic T lymphocytes

OO Yang, H Lin, M Dagarag, HL Ng, RB Effros… - Virology, 2005 - Elsevier
OO Yang, H Lin, M Dagarag, HL Ng, RB Effros, CH Uittenbogaart
Virology, 2005Elsevier
Cytotoxic T lymphocyte (CTL) senescence may be an important mechanism of immune
failure in HIV-1 infection. We find that senescence of HIV-1-specific CTL clones causes loss
of killing activity, preventable by transduction with telomerase. Furthermore, senescence is
associated with reduced expression of the effector molecules granzyme and perforin,
suggesting CTL “exhaustion” can result in hypofunction. These results agree with other
studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest …
Cytotoxic T lymphocyte (CTL) senescence may be an important mechanism of immune failure in HIV-1 infection. We find that senescence of HIV-1-specific CTL clones causes loss of killing activity, preventable by transduction with telomerase. Furthermore, senescence is associated with reduced expression of the effector molecules granzyme and perforin, suggesting CTL “exhaustion” can result in hypofunction. These results agree with other studies showing that HIV-1-specific CTL exhibit abnormal phenotypes in vivo, and suggest the possibility that chronic turnover is an important mechanism of antiviral failure in HIV-1 infection.
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