[HTML][HTML] Inhibition of mammalian target of rapamycin signaling by 2-(morpholin-1-yl) pyrimido [2, 1-α] isoquinolin-4-one

LM Ballou, ES Selinger, JY Choi… - Journal of Biological …, 2007 - ASBMB
Signaling through the mammalian target of rapamycin (mTOR) is hyperactivated in many
human tumors, including hamartomas associated with tuberous sclerosis complex (TSC).
Several small molecules such as LY294002 inhibit mTOR kinase activity, but they also
inhibit phosphatidylinositol 3-kinase (PI3K) at similar concentrations. Compound 401 is a
synthetic inhibitor of DNA-dependent protein kinase (DNA-PK) that also targets mTOR but
not PI3K in vitro (Griffin, RJ, Fontana, G., Golding, BT, Guiard, S., Hardcastle, IR, Leahy, JJ …