The fractalkine receptor CX3CR1 protects against liver fibrosis by controlling differentiation and survival of infiltrating hepatic monocytes

KR Karlmark, HW Zimmermann, C Roderburg… - Hepatology, 2010 - journals.lww.com
Chemokines modulate inflammatory responses that are prerequisites for organ fibrosis upon
liver injury. Monocyte-derived hepatic macrophages are critical for the development,
maintenance, and resolution of hepatic fibrosis. The specific role of monocyte-associated
chemokine (C-X3-C motif) receptor 1 (CX 3 CR1) and its cognate ligand fractalkine
[chemokine (C-X3-C motif) ligand 1)] in liver inflammation and fibrosis is currently unknown.
We examined 169 patients with chronic liver diseases and 84 healthy controls; we found that …