[HTML][HTML] Agrin binds to the N-terminal region of Lrp4 protein and stimulates association between Lrp4 and the first immunoglobulin-like domain in muscle-specific …
W Zhang, AS Coldefy, SR Hubbard… - Journal of Biological …, 2011 - ASBMB
Neuromuscular synapse formation depends upon coordinated interactions between motor
neurons and muscle fibers, leading to the formation of a highly specialized postsynaptic
membrane and a highly differentiated nerve terminal. Synapse formation begins as motor
axons approach muscles that are prepatterned in the prospective synaptic region in a
manner that depends upon Lrp4, a member of the LDL receptor family, and muscle-specific
kinase (MuSK), a receptor tyrosine kinase. Motor axons supply Agrin, which binds Lrp4 and …
neurons and muscle fibers, leading to the formation of a highly specialized postsynaptic
membrane and a highly differentiated nerve terminal. Synapse formation begins as motor
axons approach muscles that are prepatterned in the prospective synaptic region in a
manner that depends upon Lrp4, a member of the LDL receptor family, and muscle-specific
kinase (MuSK), a receptor tyrosine kinase. Motor axons supply Agrin, which binds Lrp4 and …