Anti-titin antibodies in myasthenia gravis: tight association with thymoma and heterogeneity of nonthymoma patients
AM Yamamoto, P Gajdos, B Eymard… - Archives of …, 2001 - jamanetwork.com
Background Titin is the major autoantigen recognized by anti–striated muscle antibodies,
which are characteristic of generalized myasthenia gravis (MG). Objective To seek a
correlation between anti-titin antibodies and other features of MG patients, including
histopathology, age at diagnosis, anti–acetylcholine receptor (anti-AChR), autoantibody
titers, and clinical severity. Methods A novel, highly specific radioligand assay was
performed on a large group of 398 patients with generalized MG. Results Among …
which are characteristic of generalized myasthenia gravis (MG). Objective To seek a
correlation between anti-titin antibodies and other features of MG patients, including
histopathology, age at diagnosis, anti–acetylcholine receptor (anti-AChR), autoantibody
titers, and clinical severity. Methods A novel, highly specific radioligand assay was
performed on a large group of 398 patients with generalized MG. Results Among …