Myasthenia gravis induced in mice by immunization with the recombinant extracellular domain of rat muscle-specific kinase (MuSK)
S Jha, K Xu, T Maruta, M Oshima, DR Mosier… - Journal of …, 2006 - Elsevier
Myasthenia gravis (MG) is mostly caused by anti-acetylcholine receptor (AChR) auto-
antibodies (Abs). Such Abs are undetectable in 10–15% of MG patients, but many have anti-
muscle-specific kinase (MuSK) Abs. We injected recombinant rat-MuSK extracellular domain
in H-2a, H-2b, H-2bm12 and H-2d mice. Certain strains exhibited exercise-induced fatigue,
tremors, weight loss, and some died after 2–3 injections. Compound muscle action
potentials showed decrement with low-frequency repetitive nerve stimulation. Miniature …
antibodies (Abs). Such Abs are undetectable in 10–15% of MG patients, but many have anti-
muscle-specific kinase (MuSK) Abs. We injected recombinant rat-MuSK extracellular domain
in H-2a, H-2b, H-2bm12 and H-2d mice. Certain strains exhibited exercise-induced fatigue,
tremors, weight loss, and some died after 2–3 injections. Compound muscle action
potentials showed decrement with low-frequency repetitive nerve stimulation. Miniature …