[HTML][HTML] Double anti-angiogenic and anti-inflammatory protein valpha targeting VEGF-A and TNF-α in retinopathy and psoriasis
Pathological angiogenesis usually involves disrupted vascular integrity, vascular leakage,
and infiltration of inflammatory cells, which are governed mainly by VEGF-A and TNF-α.
Although many inhibitors targeting either VEGF-A or TNF-α have been developed, there is
no single inhibitor molecule that simultaneously targets both molecules. Here, we designed
and generated a novel chimeric decoy receptor (Valpha) that can simultaneously bind to
VEGF-A and TNF-α and block their actions. In this experimental design, we have shown that …
and infiltration of inflammatory cells, which are governed mainly by VEGF-A and TNF-α.
Although many inhibitors targeting either VEGF-A or TNF-α have been developed, there is
no single inhibitor molecule that simultaneously targets both molecules. Here, we designed
and generated a novel chimeric decoy receptor (Valpha) that can simultaneously bind to
VEGF-A and TNF-α and block their actions. In this experimental design, we have shown that …