Inhaled nitric oxide improves survival rates during hypoxia in a sickle cell (SAD) mouse model
R Martinez-Ruiz, P Montero-Huerta… - The Journal of the …, 2001 - pubs.asahq.org
Background The hallmark of sickle cell disease (SCD) is erythrocyte sickling during
deoxygenation of the abnormal hemoglobin S (HbS). When HbS is deoxygenated, it
aggregates into polymers, resulting in distortion of the erythrocyte structure, producing
microvascular thrombosis and ischemia. The transgenic SAD mouse produces three types of
human hemoglobin: S, Antilles, and D-Punjab (HbSAD) and provides an animal model for
SCD. We studied the effects of nitric oxide (NO) breathing at various doses and time …
deoxygenation of the abnormal hemoglobin S (HbS). When HbS is deoxygenated, it
aggregates into polymers, resulting in distortion of the erythrocyte structure, producing
microvascular thrombosis and ischemia. The transgenic SAD mouse produces three types of
human hemoglobin: S, Antilles, and D-Punjab (HbSAD) and provides an animal model for
SCD. We studied the effects of nitric oxide (NO) breathing at various doses and time …