Loss of bombesin-induced feeding suppression in gastrin-releasing peptide receptor-deficient mice

LL Hampton, EE Ladenheim… - Proceedings of the …, 1998 - National Acad Sciences
LL Hampton, EE Ladenheim, M Akeson, JM Way, HC Weber, VE Sutliff, RT Jensen, LJ Wine…
Proceedings of the National Academy of Sciences, 1998National Acad Sciences
The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian
bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate
diverse biological responses including secretion, neuromodulation, chemotaxis, and growth.
The X chromosome-linked GRP-R gene is expressed widely during embryonic development
and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult.
Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce …
The gastrin-releasing peptide receptor (GRP-R) is one of three members of the mammalian bombesin subfamily of seven-transmembrane G protein-coupled receptors that mediate diverse biological responses including secretion, neuromodulation, chemotaxis, and growth. The X chromosome-linked GRP-R gene is expressed widely during embryonic development and predominantly in gastrointestinal, neuronal, and neuroendocrine systems in the adult. Surprisingly, gene-targeted mice lacking a functional GRP-R gene develop and reproduce normally and show no gross phenotypic abnormalities. However, peripheral administration of bombesin at dosages up to 32 nmol/kg to such mice had no effect on the suppression of glucose intake, whereas normal mice showed a dose-dependent suppression of glucose intake. These data suggest that selective agonists for the GRP-R may be useful in inducing satiety.
National Acad Sciences