[HTML][HTML] Tumor necrosis factor (TNF) receptor superfamily member TACI is a high affinity receptor for TNF family members APRIL and BLyS

Y Wu, D Bressette, JA Carrell, T Kaufman… - Journal of Biological …, 2000 - ASBMB
An expression cloning approach was employed to identify the receptor for B-lymphocyte
stimulator (BLyS) and identified the tumor necrosis factor receptor superfamily member TACI
as a BLyS-binding protein. Expression of TACI in HEK293T cells confers on the cells the
ability to bind BLyS with subnanomolar affinity. Furthermore, a TACI-Fc fusion protein
recognizes both the cleaved, soluble form of BLyS as well as the membrane BLyS present
on the cell surface of a recombinant cell line. TACI mRNA is found predominantly in B-cells …