Chapter two intraflagellar transport (IFT): role in ciliary assembly, resorption and signalling

LB Pedersen, JL Rosenbaum - Current topics in developmental biology, 2008 - Elsevier
Cilia and flagella have attracted tremendous attention in recent years as research
demonstrated crucial roles for these organelles in coordinating a number of physiologically
and developmentally important signaling pathways, including the platelet‐derived growth
factor receptor (PDGFR) α, Sonic hedgehog, polycystin, and Wnt pathways. In addition, the
realization that defective assembly or function of cilia can cause a plethora of diseases and
developmental defects (“ciliopathies”) has increased focus on the mechanisms by which …