[HTML][HTML] The role of interleukin-1β in human trophoblast motility
N Prutsch, V Fock, P Haslinger, S Haider, C Fiala… - Placenta, 2012 - Elsevier
The pleiotropic cytokine interleukin-1β (IL-1β) can promote physiological cell migration, as
well as cancer cell invasion and metastasis. Its role in human trophoblast invasion, however,
has not been satisfactorily answered since direct, indirect as well as no effects on
trophoblast motility have been published. Therefore, the role of IL-1β has been re-evaluated
by exclusively using human primary trophoblast model systems. Immunofluorescence of first
trimester placentae indicated IL-1 receptor 1 (IL-1R1) protein expression in first trimester …
well as cancer cell invasion and metastasis. Its role in human trophoblast invasion, however,
has not been satisfactorily answered since direct, indirect as well as no effects on
trophoblast motility have been published. Therefore, the role of IL-1β has been re-evaluated
by exclusively using human primary trophoblast model systems. Immunofluorescence of first
trimester placentae indicated IL-1 receptor 1 (IL-1R1) protein expression in first trimester …