The metabolic property of skeletal muscle adapts in response to an increased physiological
demand by altering substrate utilization and gene expression. The calcium-regulated
serine/threonine protein phosphatase calcineurin has been implicated in the transduction of
motor neuron signals to alter gene expression programs in skeletal muscle. We utilized
transgenic mice that overexpress an activated form of calcineurin in skeletal muscle (MCK-
CnA*) to investigate the impact of calcineurin activation on metabolic properties of skeletal …