Postulated role of inter-domain interaction within the ryanodine receptor in Ca2+ channel regulation
N Ikemoto, T Yamamoto - Trends in cardiovascular medicine, 2000 - Elsevier
Key steps of excitation-contraction (EC) coupling are (1) binding of the activator portion of
the dihydropyridine (DHP) receptor (in skeletal muscle) or binding of the Ca2+ entered
through the DHP receptor (in cardiac muscle) to the ryanodine receptor (RyR),(2) a global
protein conformational change of the RyR, and (3) opening of the RyR Ca2+ channel,
leading to muscle contraction. The conformational change (step 2) plays a major role in the
Ca2+ channel regulation, and a number of “regulatory domains” must be involved in this …
the dihydropyridine (DHP) receptor (in skeletal muscle) or binding of the Ca2+ entered
through the DHP receptor (in cardiac muscle) to the ryanodine receptor (RyR),(2) a global
protein conformational change of the RyR, and (3) opening of the RyR Ca2+ channel,
leading to muscle contraction. The conformational change (step 2) plays a major role in the
Ca2+ channel regulation, and a number of “regulatory domains” must be involved in this …