[HTML][HTML] Calcium signal transmission between ryanodine receptors and mitochondria
G Szalai, G Csordás, BM Hantash, AP Thomas… - Journal of Biological …, 2000 - ASBMB
Control of energy metabolism by increases of mitochondrial matrix [Ca 2+]([Ca 2+] m) may
represent a fundamental mechanism to meet the ATP demand imposed by heart
contractions, but the machinery underlying propagation of [Ca 2+] signals from ryanodine
receptor Ca 2+ release channels (RyR) to the mitochondria remains elusive. Using
permeabilized cardiac (H9c2) cells we investigated the cytosolic [Ca 2+]([Ca 2+] c) and [Ca
2+] m signals elicited by activation of RyR. Caffeine, Ca 2+, and ryanodine evoked [Ca 2+] c …
represent a fundamental mechanism to meet the ATP demand imposed by heart
contractions, but the machinery underlying propagation of [Ca 2+] signals from ryanodine
receptor Ca 2+ release channels (RyR) to the mitochondria remains elusive. Using
permeabilized cardiac (H9c2) cells we investigated the cytosolic [Ca 2+]([Ca 2+] c) and [Ca
2+] m signals elicited by activation of RyR. Caffeine, Ca 2+, and ryanodine evoked [Ca 2+] c …