Toll-like receptor 7 and 9 defects in common variable immunodeficiency

EY Joyce, AK Knight, L Radigan, TU Marron… - Journal of allergy and …, 2009 - Elsevier
BACKGROUND: Common variable immunodeficiency (CVID) is characterized by
hypogammaglobulinemia, reduced numbers of peripheral blood isotype-switched memory B
cells, and loss of plasma cells. OBJECTIVE: Because Toll-like receptor (TLR) activation of B
cells can initiate and potentially sustain normal B cell functions, we examined functional
outcomes of TLR7 and TLR9 signaling in CVID B cells. METHODS: TLR7-mediated, TLR7/8-
mediated, and TLR9-mediated cell proliferation, isotype switch, and immunoglobulin …