[HTML][HTML] Temporal perturbation of tyrosine phosphoproteome dynamics reveals the system-wide regulatory networks

M Oyama, H Kozuka-Hata, S Tasaki, K Semba… - Molecular & Cellular …, 2009 - ASBMB
Signal transduction systems are known to widely regulate complex biological events such as
cell proliferation and differentiation. Because phosphotyrosine-dependent networks play a
key role in transmitting signals, a comprehensive and fine description of their dynamic
behavior can lead us to systematically analyze the regulatory mechanisms that result in
each biological effect. Here we established a mass spectrometry-based framework for
analyzing tyrosine phosphoproteome dynamics through temporal network perturbation. A …