Tumour necrosis factor-α and apoptosis in the rat temporomandibular joint

R Spears, R Oakes, LL Bellinger, B Hutchins - Archives of oral biology, 2003 - Elsevier
The purpose of this investigation was to investigate the roles that tumour necrosis factor-α
(TNF-α) and apoptosis play during acute inflammation of the temporomandibular joint (TMJ).
Adult male Sprague–Dawley rats were injected with complete Freund's adjuvant (CFA) into
the TMJ or kept as uninjected controls. The TMJ tissues were removed 2 days post-injection
to mimic conditions of acute inflammation and analysed for changes in expression of TNF-α,
the receptor TNF-R1, caspase-3 and-8, and apoptosis. Concentrations of TNF-α, TNF-R1 …