Severe acute myopathy induced by isotretinoin

P Fiallo, AG Tagliapietra - Archives of dermatology, 1996 - jamanetwork.com
Side effects of isotretinoin treatment most commonly involve the skin, mucous membranes,
and musculoskeletal system, but are usually mild and dose dependent. We describe 2
patients with nodulocystic acne in whom isotretinoin therapy was associated with the
development of severe acute myopathy. Report of Cases. A 19-year-old woman and a 20-
year-old man presented with recalcitrant nodulocystic acne unresponsive to various types of
treatment, all of which had been discontinued several weeks previously. Apart from acne …