Rethinking iron regulation and assessment in iron deficiency, anemia of chronic disease, and obesity: introducing hepcidin
L Tussing-Humphreys, C Pustacioglu, E Nemeth… - Journal of the Academy …, 2012 - Elsevier
Adequate iron availability is essential to human development and overall health. Iron is a
key component of oxygen-carrying proteins, has a pivotal role in cellular metabolism, and is
essential to cell growth and differentiation. Inadequate dietary iron intake, chronic and acute
inflammatory conditions, and obesity are each associated with alterations in iron
homeostasis. Tight regulation of iron is necessary because iron is highly toxic and human
beings can only excrete small amounts through sweat, skin and enterocyte sloughing, and …
key component of oxygen-carrying proteins, has a pivotal role in cellular metabolism, and is
essential to cell growth and differentiation. Inadequate dietary iron intake, chronic and acute
inflammatory conditions, and obesity are each associated with alterations in iron
homeostasis. Tight regulation of iron is necessary because iron is highly toxic and human
beings can only excrete small amounts through sweat, skin and enterocyte sloughing, and …