[PDF][PDF] The role of adjuvant chemotherapy in early-stage and locally advanced non-small cell lung cancer
M Shapiro - Cleve. Clin. J. Med, 2012 - scholar.archive.org
■ ABSTRACT Adjuvant chemotherapy benefits only a small proportion of patients in the
setting of resected early-stage non–small cell lung cancer, and in unselected patients, any
benefit is modest. Analysis of clinical trials of adjuvant chemotherapy revealed that
differential expression of DNA repair proteins and a 15-gene expression profile affected
outcomes with treatment. Biomarkers and gene expression profiles are now being studied in
prospective clinical trials to gauge their value in selection of adjuvant therapy and …
setting of resected early-stage non–small cell lung cancer, and in unselected patients, any
benefit is modest. Analysis of clinical trials of adjuvant chemotherapy revealed that
differential expression of DNA repair proteins and a 15-gene expression profile affected
outcomes with treatment. Biomarkers and gene expression profiles are now being studied in
prospective clinical trials to gauge their value in selection of adjuvant therapy and …
The evolving role of targeted therapy in early-stage and locally advanced non-small cell lung cancer
H West - Current oncology reports, 2011 - Springer
Many of the leading developments in management of non-small cell lung cancer (NSCLC)
have been provided by the integration of specific targeted therapies either in combination
with a backbone of standard chemotherapy or as a single agent. Agents that inhibit a
specific pathway, such as that triggered by the activity of the epidermal growth factor
receptor, or a regulatory process like angiogenesis, have made it possible to markedly
increase response rates and extend survival, sometimes dramatically, along with a favorable …
have been provided by the integration of specific targeted therapies either in combination
with a backbone of standard chemotherapy or as a single agent. Agents that inhibit a
specific pathway, such as that triggered by the activity of the epidermal growth factor
receptor, or a regulatory process like angiogenesis, have made it possible to markedly
increase response rates and extend survival, sometimes dramatically, along with a favorable …