[HTML][HTML] The transcription factor EGR-1 suppresses transformation of human fibrosarcoma HT1080 cells by coordinated induction of transforming growth factor-β1 …
C Liu, J Yao, I de Belle, RP Huang, E Adamson… - Journal of Biological …, 1999 - ASBMB
Re-expression of EGR-1 in fibrosarcoma HT1080 suppresses transformation including
tumorigenicity (Huang, R.-P., Liu, C., Fan, Y., Mercola, D., and Adamson, E.(1995) Cancer
Res. 55, 5054–5062) owing in part to up-regulation of the transforming growth factor (TGF)-
β1 promoter by EGR-1 which suppresses growth by an autocrine mechanism (Liu, C.,
Adamson, E., and Mercola, D.(1996) Proc. Natl. Acad. Sci. USA 93, 11831–11836). Here we
show that enhanced cell attachment contributes to the suppression via increased secretion …
tumorigenicity (Huang, R.-P., Liu, C., Fan, Y., Mercola, D., and Adamson, E.(1995) Cancer
Res. 55, 5054–5062) owing in part to up-regulation of the transforming growth factor (TGF)-
β1 promoter by EGR-1 which suppresses growth by an autocrine mechanism (Liu, C.,
Adamson, E., and Mercola, D.(1996) Proc. Natl. Acad. Sci. USA 93, 11831–11836). Here we
show that enhanced cell attachment contributes to the suppression via increased secretion …