[HTML][HTML] Efficient TGF-β induction of the Smad7 gene requires cooperation between AP-1, Sp1, and Smad proteins on the mouse Smad7 promoter
G Brodin, A Åhgren, P ten Dijke, CH Heldin… - Journal of Biological …, 2000 - ASBMB
Sma-and Mad-related protein 7 (Smad7) is an antagonist of transforming growth factor-β
(TGF-β) signaling, which has been shown to be induced by TGF-β itself and also by other
stimuli. In an effort to understand the molecular mechanisms underlying the transcriptional
regulation of the Smad7 gene by TGF-β, we cloned and functionally characterized a mouse
genomic DNA fragment encompassing the mouse Smad7 proximal promoter. This region
was found to contain a CpG island and to be devoid of a classical TATA box. Cloned …
(TGF-β) signaling, which has been shown to be induced by TGF-β itself and also by other
stimuli. In an effort to understand the molecular mechanisms underlying the transcriptional
regulation of the Smad7 gene by TGF-β, we cloned and functionally characterized a mouse
genomic DNA fragment encompassing the mouse Smad7 proximal promoter. This region
was found to contain a CpG island and to be devoid of a classical TATA box. Cloned …