[HTML][HTML] Regulation of Smad7 promoter by direct association with Smad3 and Smad4
RP Nagarajan, J Zhang, W Li, Y Chen - Journal of Biological Chemistry, 1999 - ASBMB
Smad7 is a regulatory Smad protein that is able to antagonize signal transduction by
transforming growth factor-β (TGF-β) and activin receptors. To characterize the regulation of
Smad7 at the transcriptional level, we isolated the promoter region of the mouse Smad7
gene. When the Smad7 promoter luciferase reporter gene (− 408 and+ 112 bp) was
expressed in human hepatoma (HepG2) cells, its transcriptional activity was increased
following TGF-β or activin treatment. In addition, this region of the Smad7 promoter was …
transforming growth factor-β (TGF-β) and activin receptors. To characterize the regulation of
Smad7 at the transcriptional level, we isolated the promoter region of the mouse Smad7
gene. When the Smad7 promoter luciferase reporter gene (− 408 and+ 112 bp) was
expressed in human hepatoma (HepG2) cells, its transcriptional activity was increased
following TGF-β or activin treatment. In addition, this region of the Smad7 promoter was …