[PDF][PDF] MEASUREMENT OF PLASMODJUM FALCIPARUAM GROVVTH RATES IN VIVO: A TEST OF MALARIA VACCINES

Q Cheng, G Lawrence, C Reed, A Stowers… - Am. J. Trop. Med …, 1997 - researchgate.net
Several prototype vaccines against the asexual blood stage of malaria are undergoing
preclinical and phase I testing. Although these vaccines have been chosen for their ability to
elicit an anti-parasite response, no practical and sensitive clinical trial procedure has been
available for measuring their impact on parasite growth. We describe a system that allows
parasite growth rates to be measured in volunteers through the incubation period. Two
necessary elements of this system are developed: suitable blood-stage Plasmodium …