[HTML][HTML] Integrin β4 regulates migratory behavior of keratinocytes by determining laminin-332 organization
BU Sehgal, PJ DeBiase, S Matzno, TL Chew… - Journal of Biological …, 2006 - ASBMB
Whether α6β4 integrin regulates migration remains controversial. β4 integrin-deficient (JEB)
keratinocytes display aberrant migration in that they move in circles, a behavior that mirrors
the circular arrays of laminin (LM)-332 in their matrix. In contrast, wild-type keratinocytes and
JEB keratinocytes, induced to express β4 integrin, assemble laminin-332 in linear tracks
over which they migrate. Moreover, laminin-332-dependent migration of JEB keratinocytes
along linear tracks is restored when cells are plated on wild-type keratinocyte matrix …
keratinocytes display aberrant migration in that they move in circles, a behavior that mirrors
the circular arrays of laminin (LM)-332 in their matrix. In contrast, wild-type keratinocytes and
JEB keratinocytes, induced to express β4 integrin, assemble laminin-332 in linear tracks
over which they migrate. Moreover, laminin-332-dependent migration of JEB keratinocytes
along linear tracks is restored when cells are plated on wild-type keratinocyte matrix …