Topical application of laminin-332 to diabetic mouse wounds
SR Sullivan, RA Underwood, RO Sigle… - Journal of …, 2007 - Elsevier
BACKGROUND: Keratinocyte migration is essential for wound healing and diabetic wound
keratinocytes migrate poorly. Keratinocyte migration and anchorage appears to be mediated
by laminin-332 (LM-332). Impaired diabetic wound healing may be due to defective LM-332
mediated keratinocyte migration. OBJECTIVE: To evaluate LM-332 expression in diabetic
(db/db) and control (db/−) mice and to test LM-332 wound healing effects when applied to
mouse wounds. METHODS: LM-332 expression in mouse wounds was evaluated using …
keratinocytes migrate poorly. Keratinocyte migration and anchorage appears to be mediated
by laminin-332 (LM-332). Impaired diabetic wound healing may be due to defective LM-332
mediated keratinocyte migration. OBJECTIVE: To evaluate LM-332 expression in diabetic
(db/db) and control (db/−) mice and to test LM-332 wound healing effects when applied to
mouse wounds. METHODS: LM-332 expression in mouse wounds was evaluated using …