The transcriptional program in the response of human fibroblasts to serum

VR Iyer, MB Eisen, DT Ross, G Schuler, T Moore… - science, 1999 - science.org
VR Iyer, MB Eisen, DT Ross, G Schuler, T Moore, JCF Lee, JM Trent, LM Staudt, J Hudson Jr
science, 1999science.org
The temporal program of gene expression during a model physiological response of human
cells, the response of fibroblasts to serum, was explored with a complementary DNA
microarray representing about 8600 different human genes. Genes could be clustered into
groups on the basis of their temporal patterns of expression in this program. Many features
of the transcriptional program appeared to be related to the physiology of wound repair,
suggesting that fibroblasts play a larger and richer role in this complex multicellular …
The temporal program of gene expression during a model physiological response of human cells, the response of fibroblasts to serum, was explored with a complementary DNA microarray representing about 8600 different human genes. Genes could be clustered into groups on the basis of their temporal patterns of expression in this program. Many features of the transcriptional program appeared to be related to the physiology of wound repair, suggesting that fibroblasts play a larger and richer role in this complex multicellular response than had previously been appreciated.
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