[HTML][HTML] Concurrent loss of heterozygosity and copy number analysis in adenoid cystic carcinoma by SNP genotyping arrays
Adenoid cystic carcinoma (ACC) is one of the most common malignancies to arise in the
salivary glands, yet very little is known of the genetic alterations that are involved in the
pathogenesis of this disease. To further examine the genetic changes that underlie ACC, we
analyzed genomic DNA obtained from 22 primary ACC and two ACC-derived cell lines by
high-density oligonucleotide single-nucleotide polymorphism genotyping arrays (Affymetrix
GeneChip® Human Mapping 100K Set). Allelotype calls were analyzed by the Haplotype …
salivary glands, yet very little is known of the genetic alterations that are involved in the
pathogenesis of this disease. To further examine the genetic changes that underlie ACC, we
analyzed genomic DNA obtained from 22 primary ACC and two ACC-derived cell lines by
high-density oligonucleotide single-nucleotide polymorphism genotyping arrays (Affymetrix
GeneChip® Human Mapping 100K Set). Allelotype calls were analyzed by the Haplotype …