Aberrant methylation in promoter-associated CpG islands of multiple genes in acute lymphoblastic leukemia
Y Yang, S Takeuchi, WK Hofmann, T Ikezoe… - Leukemia research, 2006 - Elsevier
Methylation profile was analyzed in 10 childhood acute lymphoblastic leukemia (ALL) and
nine adult ALL cases. Four genes (p15, p16, RARβ, FHIT) had methylation in both diseases,
four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two
genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARβ was
more frequent in adult ALL than that in childhood ALL (p= 0.01). The number of patients with
methylation of multiple genes was higher in adult ALL than that in childhood ALL (p= 0.006) …
nine adult ALL cases. Four genes (p15, p16, RARβ, FHIT) had methylation in both diseases,
four genes (p14, Rb, MLH1, DAPK) showed no methylation in both diseases, and the two
genes (APC, RIZ) demonstrated methylation only in adult ALL. Methylation of the RARβ was
more frequent in adult ALL than that in childhood ALL (p= 0.01). The number of patients with
methylation of multiple genes was higher in adult ALL than that in childhood ALL (p= 0.006) …