Normal immune responses stimulated by pathogenic and environmental antigens generate
memory T cells that react with donor antigens and no currently used immunosuppressive
drug completely inhibits memory T-cell function. While donor-reactive memory T cells clearly
compromise graft outcomes, mechanisms utilized by memory T cells to promote rejection are
largely unknown. In this study, we investigated how early endogenous memory cells infiltrate
and express effector function in cardiac allografts. Endogenous CD8 memory T cells in …