The ins and outs of leukocyte integrin signaling

CL Abram, CA Lowell - Annual review of immunology, 2009 - annualreviews.org
CL Abram, CA Lowell
Annual review of immunology, 2009annualreviews.org
Integrins are the principal cell adhesion receptors that mediate leukocyte migration and
activation in the immune system. These receptors signal bidirectionally through the plasma
membrane in pathways referred to as inside-out and outside-in signaling. Each of these
pathways is mediated by conformational changes in the integrin structure. Such changes
allow high-affinity binding of the receptor with counter-adhesion molecules on the vascular
endothelium or extracellular matrix and lead to association of the cytoplasmic tails of the …
Integrins are the principal cell adhesion receptors that mediate leukocyte migration and activation in the immune system. These receptors signal bidirectionally through the plasma membrane in pathways referred to as inside-out and outside-in signaling. Each of these pathways is mediated by conformational changes in the integrin structure. Such changes allow high-affinity binding of the receptor with counter-adhesion molecules on the vascular endothelium or extracellular matrix and lead to association of the cytoplasmic tails of the integrins with intracellular signaling molecules. Leukocyte functional responses resulting from outside-in signaling include migration, proliferation, cytokine secretion, and degranulation. Here, we review the key signaling events that occur in the inside-out versus outside-in pathways, highlighting recent advances in our understanding of how integrins are activated by a variety of stimuli and how they mediate a diverse array of cellular responses.
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