[HTML][HTML] PPARδ agonism activates fatty acid oxidation via PGC-1α but does not increase mitochondrial gene expression and function
S Kleiner, V Nguyen-Tran, O Baré, X Huang… - Journal of Biological …, 2009 - ASBMB
PPARδ (peroxisome proliferator-activated receptor δ) is a regulator of lipid metabolism and
has been shown to induce fatty acid oxidation (FAO). PPARδ transgenic and knock-out mice
indicate an involvement of PPARδ in regulating mitochondrial biogenesis and oxidative
capacity; however, the precise mechanisms by which PPARδ regulates these pathways in
skeletal muscle remain unclear. In this study, we determined the effect of selective PPARδ
agonism with the synthetic ligand, GW501516, on FAO and mitochondrial gene expression …
has been shown to induce fatty acid oxidation (FAO). PPARδ transgenic and knock-out mice
indicate an involvement of PPARδ in regulating mitochondrial biogenesis and oxidative
capacity; however, the precise mechanisms by which PPARδ regulates these pathways in
skeletal muscle remain unclear. In this study, we determined the effect of selective PPARδ
agonism with the synthetic ligand, GW501516, on FAO and mitochondrial gene expression …