[HTML][HTML] Extrasynaptic membrane trafficking regulated by GluR1 serine 845 phosphorylation primes AMPA receptors for long-term potentiation
MC Oh, VA Derkach, ES Guire, TR Soderling - Journal of Biological …, 2006 - ASBMB
Enhancement of synaptic transmission, as occurs in long-term potentiation (LTP), can result
from several mechanisms that are regulated by phosphorylation of the AMPA-type glutamate
receptor (AMPAR). Using a quantitative assay of net serine 845 (Ser-845) phosphorylation
in the GluR1 subunit of AMPARs, we investigated the relationship between phospho-Ser-
845, GluR1 surface expression, and synaptic strength in hippocampal neurons. About 15%
of surface AMPARs in cultured neurons were phosphorylated at Ser-845 basally, whereas …
from several mechanisms that are regulated by phosphorylation of the AMPA-type glutamate
receptor (AMPAR). Using a quantitative assay of net serine 845 (Ser-845) phosphorylation
in the GluR1 subunit of AMPARs, we investigated the relationship between phospho-Ser-
845, GluR1 surface expression, and synaptic strength in hippocampal neurons. About 15%
of surface AMPARs in cultured neurons were phosphorylated at Ser-845 basally, whereas …