Lyp breakdown and autoimmunity

TW Behrens - Nature genetics, 2011 - nature.com
Nature genetics, 2011nature.com
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A new study shows that the PTPN22 coding variant associated with autoimmunity is a loss-of-function allele that causes the protein tyrosine phosphatase encoded by PTPN22 to undergo accelerated degradation, resulting in enhanced signaling in several immune cell types.
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