Role of insulin-like growth factor-1 in the regulation of skeletal growth
S Mohan, C Kesavan - Current osteoporosis reports, 2012 - Springer
S Mohan, C Kesavan
Current osteoporosis reports, 2012•SpringerThe importance of the insulin-like growth factor (IGF)-I axis in the regulation of bone size and
bone mineral density, two important determinants of bone strength, has been well
established from clinical studies involving patients with growth hormone deficiency and IGF-I
gene disruption. Data from transgenic animal studies involving disruption and
overexpression of components of the IGF-I axis also provide support for a key role for IGF-I in
bone metabolism. IGF-I actions in bone are subject to regulation by systemic hormones …
bone mineral density, two important determinants of bone strength, has been well
established from clinical studies involving patients with growth hormone deficiency and IGF-I
gene disruption. Data from transgenic animal studies involving disruption and
overexpression of components of the IGF-I axis also provide support for a key role for IGF-I in
bone metabolism. IGF-I actions in bone are subject to regulation by systemic hormones …
Abstract
The importance of the insulin-like growth factor (IGF)-I axis in the regulation of bone size and bone mineral density, two important determinants of bone strength, has been well established from clinical studies involving patients with growth hormone deficiency and IGF-I gene disruption. Data from transgenic animal studies involving disruption and overexpression of components of the IGF-I axis also provide support for a key role for IGF-I in bone metabolism. IGF-I actions in bone are subject to regulation by systemic hormones, local growth factors, as well as mechanical stress. In this review we describe findings from various genetic mouse models that pertain to the role of endocrine and local sources of IGF-I in the regulation of skeletal growth.
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