Nucleotide excision repair (NER) is a multi-step DNA repair mechanism that removes helix-
distorting modified nucleotides from the genome. NER is divided into two subpathways
depending on the location of DNA damage in the genome and how it is first detected. Global
genome NER identifies and repairs DNA lesions throughout the genome. This subpathway
of NER primarily protects against the accumulation of mutations in the genome.
Transcription-coupled (TC)-NER rapidly repairs lesions in the transcribed strand of DNA that …