Terminal differentiation of mammalian erythroid progenitors involves 4–5 cell divisions and
induction of many erythroid important genes followed by chromatin and nuclear
condensation and enucleation. The protein levels of c-Myc (Myc) are reduced dramatically
during late stage erythroid maturation, coinciding with cell cycle arrest in G 1 phase and
enucleation, suggesting possible roles for c-Myc in either or both of these processes. Here
we demonstrate that ectopic Myc expression affects terminal erythroid maturation in a dose …