Lipopolysaccharide treatment of rats alters antigen expression and oxidative metabolism in hepatic macrophages and endothelial cells
TW Mc Closkey, JA Todaro, DL Laskin - Hepatology, 1992 - journals.lww.com
Endothelial cells and macrophages are located within the hepatic sinusoids. These two cell
types play an important role in the clearance of bacterially derived lipopolysaccharide from
the portal circulation. Our laboratory has previously demonstrated that treatment of rats with
lipopolysaccharide results in the accumulation of macrophages in the liver that display
properties of activated mononuclear phagocytes. This study was designed to analyze the
effects of lipopolysaccharide on hepatic endothelial cells. Female Sprague–Dawley rats …
types play an important role in the clearance of bacterially derived lipopolysaccharide from
the portal circulation. Our laboratory has previously demonstrated that treatment of rats with
lipopolysaccharide results in the accumulation of macrophages in the liver that display
properties of activated mononuclear phagocytes. This study was designed to analyze the
effects of lipopolysaccharide on hepatic endothelial cells. Female Sprague–Dawley rats …