Toxicity of azathioprine and monocrotaline in murine sinusoidal endothelial cells and hepatocytes: the role of glutathione and relevance to hepatic venoocclusive …
LD DeLeve, X Wang, JF Kuhlenkamp, N Kaplowitz - Hepatology, 1996 - journals.lww.com
The mechanisms leading to hepatic venoocclusive disease (HVOD) remain largely
unknown. Azathioprine and monocrotaline were studied as part of a series of studies looking
at a variety of toxins that induce HVOD to find common features that might be of pathogenic
significance. In a previous study, dacarbazine showed selective in vitro toxicity to sinusoidal
endothelial cells (SEC) compared with hepatocytes and a key role for SEC glutathione
(GSH) was demonstrated. Murine SEC and hepatocytes were isolated and studied in …
unknown. Azathioprine and monocrotaline were studied as part of a series of studies looking
at a variety of toxins that induce HVOD to find common features that might be of pathogenic
significance. In a previous study, dacarbazine showed selective in vitro toxicity to sinusoidal
endothelial cells (SEC) compared with hepatocytes and a key role for SEC glutathione
(GSH) was demonstrated. Murine SEC and hepatocytes were isolated and studied in …