Prostaglandin F2α and D2 release from primary Ito cell cultures after stimulation with noradrenaline and ATP but not adenosine
A Athari, K Hänecke, K Jungermann - Hepatology, 1994 - journals.lww.com
Rat liver Ito cells were cultured for 24 hr with 20% newborn calf serum. Stimulation with the
sympathetic neurotransmitter noradrenaline (0.1 μmol/L to 1 mmol/L) led to a dose–
dependent increase in prostaglandin F 2α release and a slightly smaller enhancement of
prostaglandin D 2 production. Prostaglandin F 2α and prostaglandin D 2 release strongly.
The relase was highest again during the first 30 sec. stimulation. Stimulation with the
possible cotransmitter ATP (10 μmol/L and 1 mmol/L ATP) also enhanced both …
sympathetic neurotransmitter noradrenaline (0.1 μmol/L to 1 mmol/L) led to a dose–
dependent increase in prostaglandin F 2α release and a slightly smaller enhancement of
prostaglandin D 2 production. Prostaglandin F 2α and prostaglandin D 2 release strongly.
The relase was highest again during the first 30 sec. stimulation. Stimulation with the
possible cotransmitter ATP (10 μmol/L and 1 mmol/L ATP) also enhanced both …