The discovery of molecules required for membrane fusion has revealed a remarkably
conserved mechanism that centers upon the formation of a complex of SNARE proteins.
However, whether the SNARE proteins or other components catalyze the final steps of
membrane fusion in vivo remains unclear. Understanding this last step depends on the
identification of molecules that act late in the fusion process. Here we demonstrate that in
Saccharomyces cerevisiae, Vac8p, a myristoylated and palmitoylated armadillo repeat …