Cholesterol and sphingomyelin are both important plasma membrane constituents in cells. It
is now becoming evident that these two lipid classes affect each other's metabolism in the
cell to an extent that was not previously appreciated. It is the aim of this review to present
recent data in the literature concerning both molecular and membrane properties of the two
lipid classes, how they interact in membranes (both biological and model), and the
consequences their mutual interaction have on different functional and metabolic processes …