Liquid chromatographic determination of mycophenolic acid and its metabolites in human kidney transplant plasma: pharmacokinetic application
FA Elbarbry, AS Shoker - Journal of Chromatography B, 2007 - Elsevier
BACKGROUND AND OBJECTIVE: Difference in the hydrophilic properties of mycophenolic
acid metabolites makes it technically difficult to simultaneously determine their plasma levels
in one analytical run. Therapeutic drug monitoring (TDM) for MPA ensures adequate MPA
exposure levels to both prevent rejection and avoid related toxicity. One measure limitation
for TDM for MPA is the availability of simple, rapid and reproducible method for
determination of MPA derivatives. METHOD: Herein we report a single method to measure …
acid metabolites makes it technically difficult to simultaneously determine their plasma levels
in one analytical run. Therapeutic drug monitoring (TDM) for MPA ensures adequate MPA
exposure levels to both prevent rejection and avoid related toxicity. One measure limitation
for TDM for MPA is the availability of simple, rapid and reproducible method for
determination of MPA derivatives. METHOD: Herein we report a single method to measure …