[HTML][HTML] The Erbin PDZ Domain Binds with High Affinity and Specificity to the Carboxyl Termini of δ-Catenin and ARVCF∗
RP Laura, AS Witt, HA Held, R Gerstner… - Journal of Biological …, 2002 - ASBMB
Erbin is a recently described member of the LAP (leucine-rich repeat and PDZ domain)
protein family. We used a C-terminally displayed phage peptide library to identify optimal
ligands for the Erbin PDZ domain. Phage-selected peptides were type 1 PDZ ligands that
bound with high affinity and specificity to the Erbin PDZ domain in vitro. These peptides most
closely resembled the C-terminal PDZ domain-binding motifs of three p120-related catenins:
δ-catenin, ARVCF, and p0071 (DSWV-COOH). Analysis of the interactions of the Erbin PDZ …
protein family. We used a C-terminally displayed phage peptide library to identify optimal
ligands for the Erbin PDZ domain. Phage-selected peptides were type 1 PDZ ligands that
bound with high affinity and specificity to the Erbin PDZ domain in vitro. These peptides most
closely resembled the C-terminal PDZ domain-binding motifs of three p120-related catenins:
δ-catenin, ARVCF, and p0071 (DSWV-COOH). Analysis of the interactions of the Erbin PDZ …