Coordinated expression of desmoglein 1 and desmocollin 1 regulates intercellular adhesion
S Getsios, EV Amargo, RL Dusek, K Ishii, L Sheu… - Differentiation, 2004 - Elsevier
Desmoglein 1 (Dsg1) is a component of desmosomes present in the upper epidermis and
can be targeted by autoimmune antibodies or bacterial toxins, resulting in skin blistering
diseases. These defects in tissue integrity are believed to result from compromised
desmosomal adhesion; yet, previous attempts to directly test the adhesive roles of
desmosomal cadherins using normally non-adherent L cells have yielded mixed results.
Here, two complementary approaches were used to better resolve the molecular …
can be targeted by autoimmune antibodies or bacterial toxins, resulting in skin blistering
diseases. These defects in tissue integrity are believed to result from compromised
desmosomal adhesion; yet, previous attempts to directly test the adhesive roles of
desmosomal cadherins using normally non-adherent L cells have yielded mixed results.
Here, two complementary approaches were used to better resolve the molecular …