[HTML][HTML] Cooperative phosphorylation of the tumor suppressor phosphatase and tensin homologue (PTEN) by casein kinases and glycogen synthase kinase 3β
AM Al-Khouri, Y Ma, SH Togo, S Williams… - Journal of Biological …, 2005 - ASBMB
The phosphatase and tensin homologue (PTEN) tumor suppressor is a phosphatidylinositol
D3-phosphatase that counteracts the effects of phosphatidylinositol 3-kinase and negatively
regulates cell growth and survival. PTEN is itself regulated by phosphorylation on multiple
serine and threonine residues in its C terminus. Previous work has implicated casein kinase
2 (CK2) as the kinase responsible for this phosphorylation. Here we showed that CK2 does
not phosphorylate all sites in PTEN and that glycogen synthase kinase 3β (GSK3β) also …
D3-phosphatase that counteracts the effects of phosphatidylinositol 3-kinase and negatively
regulates cell growth and survival. PTEN is itself regulated by phosphorylation on multiple
serine and threonine residues in its C terminus. Previous work has implicated casein kinase
2 (CK2) as the kinase responsible for this phosphorylation. Here we showed that CK2 does
not phosphorylate all sites in PTEN and that glycogen synthase kinase 3β (GSK3β) also …